- Cell Line: SU-DHL-4
- Synonyms:
- SU-DHL-4
- SUDHL4
- SUDHL-4
- SuDHL-4
- SuDHL 4
- Stanford University-Diffuse Histiocytic Lymphoma-4
- Culture Type: Cell line
- Keywords: Human B Cell Lymphoma Cell Line
- Description: Established from the peritoneal effusion of a Caucasian, 38-year-old, male patient with diffuse large B-cell lymphoma germinal center B-cell type
- Origin:
- Organism:
- Species: Human (Homo sapiens)
- Age: 38 years
- Ethnicity: Caucasian
- Gender: Male
- Tissue: Peritoneal effusion
- Disease: diffuse large B-cell lymphoma germinal center B-cell type
- Primary/Metastasis: Metastatic (DepMap)
- Collection site:
- Pleural effusion (DepMap)
- Peritoneal effusion (Cellosaurus)
- Year of origin:
- Country of Origin:-
- Organism:
- Cell line features:
- Cell Type: B lymphocyte
- Morphology: Lymphoblast-like,
- Growth mode: Single round cells growing in suspension
- Life span: Infinite (continuous culture)
- Karyotype: Human hyperdiploid karyotype with 4% polyploidy
- Doubling time: ~40 hours
- Microsatellite instability: Stable
- Special features:
- Relatively high expression levels of Bax, Bak, AIF
- High caspase-9 activity
- Product:-
- Soft agar colony formation assay:-
- Tumorigenicity:-
- Gene expression:-
- Sequence variations:
- TP53 (R273C mutation, Likely Oncogenic, Likely Loss-of-function, Homozygous)
- EZH2 (Y646S mutation, Oncogenic, Likely Gain-of-function, Heterozygous)
- For information, please visit
- https://depmap.org/portal/cell_line/ACH-000365?tab=mutations
- https://depmap.org/portal/cell_line/ACH-000365?tab=fusions
- Cell Type: B lymphocyte
- Handling and maintenance:
- Applications:
- 3D cell culture
- Immunology
- Cell Line Availability: The cell line can be obtained from the following sources.
- American Type Culture Collection (ATCC): Product link
- DSMZ-German Collection of Microorganisms and Cell Cultures GmbH: Product link
- Cytion: Product link
- References
- Images:
- SU-DHL-4 cell line image link 1 (Source: ATCC)
- SU-DHL-4 cell line image link 2 (Source: DSMZ)
- SU-DHL-4 cell line image link 3 (Source: DSMZ)
- SU-DHL-4 cell line image link 4 (Source: DSMZ)
- SU-DHL-4 cell line image link 5 (Source: DSMZ)
- Abbreviations
- BSL (Biosafety level)
- FBS (Fetal Bovine Serum)
- DMSO (Dimethyl sulfoxide)
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