- Zinc undecylenate is an organometallic compound with the chemical formula C22H38O4Zn, consisting of zinc bound to undecylenic acid, a monounsaturated fatty acid with antifungal properties. It appears as a fine white to off-white powder that is insoluble in water but soluble in oils and organic solvents. The compound is formed by the reaction of zinc oxide with undecylenic acid, resulting in a salt where zinc is coordinated with two carboxylate groups. Its structure and fatty acid backbone give it both lipophilic and bioactive characteristics.
- Zinc undecylenate is primarily used for its antifungal and antimicrobial properties. It has long been a component of topical medications for treating fungal infections of the skin, particularly tinea pedis (athlete’s foot) and tinea corporis (ringworm). Its effectiveness comes from the undecylenic acid moiety, which disrupts fungal cell membranes and inhibits fungal growth, while the zinc component contributes additional astringent and antiseptic effects, helping to dry lesions and soothe irritated skin.
- Pharmaceutical formulations containing zinc undecylenate are often presented in the form of powders, creams, or ointments, sometimes in combination with other antifungal agents or excipients that enhance skin adherence and efficacy. Because of its mild nature and relatively low toxicity, it is considered safe for over-the-counter (OTC) use, although prolonged or excessive use should be avoided to prevent skin irritation.
- In addition to medical applications, zinc undecylenate has found occasional use in cosmetics and personal care products, such as foot powders and deodorants, where its antimicrobial and deodorizing effects are desirable. It may also be incorporated into certain veterinary treatments for fungal infections in animals.
- Zinc undecylenate is generally well-tolerated, but as with any topical agent, it can cause localized irritation in sensitive individuals. Regulatory bodies such as the FDA recognize it as an active ingredient in antifungal drug products, but it is subject to concentration limits and formulation guidelines. Overall, zinc undecylenate is a valuable compound combining the therapeutic benefits of zinc with the natural antifungal efficacy of undecylenic acid, offering a well-rounded approach to treating superficial fungal infections.
