- Amoxicillin is a broad-spectrum penicillin antibiotic that works by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins (PBPs). This interference with peptidoglycan cross-linking leads to bacterial cell wall disruption and ultimately cell death.
- The medication is widely prescribed for various bacterial infections, including respiratory tract infections, ear infections, urinary tract infections, and skin infections. Its enhanced absorption compared to ampicillin and broader spectrum of activity against gram-positive and some gram-negative bacteria make it a frequently chosen first-line antibiotic.
- Amoxicillin plays a vital role in H. pylori eradication therapy when combined with a proton pump inhibitor and another antibiotic, typically clarithromycin. Its effectiveness against H. pylori, combined with good tissue penetration and relatively low resistance rates, makes it a cornerstone of standard triple therapy regimens. The medication’s bactericidal action, enhanced by the acid-suppressing effect of PPIs, contributes to successful bacterial clearance.
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