Category: Lab Notes: Bioinformatics

Learn how to search GenBank effectively using accession numbers, organism names, gene names, sequence types, filters, and other search strategies to find relevant nucleotide sequences.

Discover the four levels of protein structure: primary, secondary, tertiary, and quaternary. Learn how amino acid sequences form complex three-dimensional proteins and influence biological function.

Discover the history and development of the Protein Data Bank (PDB), from its establishment in 1971 to its evolution into a global scientific archive supporting structural biology, medicine, bioinformatics, and drug discovery.

The Protein Data Bank (PDB) is a global open-access resource containing three-dimensional structures of proteins, DNA, RNA, and other biological macromolecules. Discover its history, structure determination methods, applications, and importance in modern science.

Discover how UniProt describes protein function using functional annotations, experimental evidence, computational prediction, Gene Ontology, catalytic activity, domains, localization, pathways, and literature.

Protein annotation in UniProt adds biological meaning to protein sequences through information about function, domains, localization, modifications, variants, evidence, literature, and other molecular characteristics.

TrEMBL is the unreviewed component of UniProtKB, providing extensive protein sequence coverage through computational annotation. Learn how TrEMBL uses automatic annotation, sequence similarity, protein domains, evidence, and other computational approaches to characterize newly available protein sequences.

Swiss-Prot is the reviewed and manually curated component of UniProtKB. Learn how Swiss-Prot provides protein sequences, functional annotations, evidence, scientific references, sequence features, domains, modifications, and other biological information.

UniProt is a major protein knowledge resource providing information on protein sequences, functions, annotations, structures, domains, taxonomy, proteomes, and scientific evidence. Explore the major components of UniProt and understand how researchers use this essential bioinformatics resource.

Bioinformatics is an interdisciplinary field that uses computational tools to analyse and interpret biological data. This article explains key databases, algorithms, applications in genomics, proteomics, systems biology, and the growing role of AI in biological research.