Category: Lab Notes: Biotechniques
Label-Free Analysis of Biological Interaction
Label-free analysis of biological interactions refers to a suite of techniques that detect and quantify biomolecular interactions without the need…
Scanning Tunneling Microscope
The Scanning Tunneling Microscope (STM) is a powerful analytical instrument that enables scientists to image and manipulate surfaces at the…
Cleavage Under Targets and Tagmentation (CUT&Tag)
Cleavage Under Targets and Tagmentation (CUT&Tag) is a modern epigenomic profiling technique designed to map protein-DNA interactions and chromatin modifications…
Chromatin Immunoprecipitation Sequencing (ChIP-seq)
Chromatin Immunoprecipitation Sequencing (ChIP-seq) is a powerful technique used to investigate the interactions between proteins and DNA within the genome. …
Single-Cell Chromatin Immunocleavage Sequencing (scChIC-seq)
Single-cell chromatin immunocleavage sequencing (scChIC-seq) is a powerful technique that combines the principles of chromatin profiling and single-cell resolution, enabling…
Electroencephalography (EEG)
Electroencephalography (EEG) is a non-invasive neurophysiological technique used to record the electrical activity of the brain through electrodes placed on…
Whole-Genome Sequencing
Whole-Genome Sequencing (WGS) is a comprehensive method used to determine the complete DNA sequence of an organism’s genome. This process…
Ion Torrent Sequencing
Ion Torrent sequencing is also known as Ion semiconductor sequencing. For more detailed information, please visit the article Ion Semiconductor…
Ion Semiconductor Sequencing
Ion semiconductor sequencing, also known as Ion Torrent sequencing, represents a significant advancement in next-generation sequencing technology. This method utilizes…
Alanine tRNA and the Birth of Sequencing: The Legacy of Robert W. Holley
In the annals of molecular biology, the sequencing of alanine transfer RNA (tRNA) from yeast stands as a monumental achievement….
Capillary Electrophoresis
Capillary electrophoresis (CE) is a powerful analytical technique used to separate ionic species based on their size-to-charge ratio. It is…
Automation of Sanger Sequencing Using Fluorescent Dideoxynucleotides and Capillary Electrophoresis
Sanger sequencing, developed by Frederick Sanger in the late 1970s, was the first widely adopted method for determining the nucleotide…
DNA Sequencer
A DNA sequencer is a laboratory instrument used to determine the precise order of nucleotides—adenine (A), thymine (T), cytosine (C),…
DNA Sequencing: Timeline of Key Events
DNA sequencing, the process of determining the precise order of nucleotides in a DNA molecule, has revolutionized biology, biotechnology, and…
Shotgun Sequencing
Shotgun sequencing is a powerful and widely used approach to DNA sequencing that involves randomly breaking a genome into numerous…