The repressive B compartment is a major feature of three-dimensional genome organization. Learn how Polycomb complexes, PRC1, PRC2, H3K27me3, H2AK119ub, TADs, chromatin loops, and nuclear organization contribute to gene repression and chromatin architecture.
Chromatin compartments organize the genome into broad active and repressive environments. Explore how Polycomb complexes, PRC1, PRC2, H3K27me3, H2AK119ub, TADs, CTCF, and cohesin interact with A/B compartments to regulate gene expression and 3D genome organization.
TADs and Polycomb domains represent distinct but interacting layers of 3D genome organization. Explore how Polycomb chromatin, PRC1, PRC2, CTCF, cohesin, chromatin loops, and TADs contribute to gene regulation.
Polycomb complexes regulate developmental genes through repressive chromatin states that interact with enhancer and promoter activity. Explore how PRC1, PRC2, histone modifications, chromatin architecture, and enhancer–promoter interactions coordinate gene regulation.
Polycomb chromatin loops and long-range interactions connect Polycomb-mediated epigenetic regulation with three-dimensional genome organization, helping coordinate the regulation of developmental and cell-identity genes.
Polycomb, CTCF, and cohesin are interconnected regulators of 3D genome organization. Explore how Polycomb chromatin, CTCF binding, cohesin-mediated looping, TADs, chromatin interactions, and developmental gene regulation intersect.
Polycomb nuclear bodies and foci are nuclear concentrations of Polycomb proteins and associated chromatin. Explore how PRC1, PRC2, H3K27me3, H2AK119ub, chromatin interactions, and 3D genome organization contribute to Polycomb nuclear organization.
Polycomb-mediated epigenetic memory allows cells to maintain patterns of gene repression through development and cell division. Learn how PRC1, PRC2, H3K27me3, H2AK119ub, and chromatin organization contribute to this dynamic regulatory process.
Polycomb response elements (PREs) are cis-regulatory DNA regions that help recruit and organize Polycomb complexes. Best characterized in Drosophila, PREs provide an important model for understanding Polycomb recruitment, H3K27me3, H2AK119ub, epigenetic memory, and developmental gene repression.
PRC1 complexes use multiple mechanisms to target chromatin, including CBX recognition of H3K27me3, KDM2B recognition of unmethylated CpG-rich DNA, transcription-factor interactions, and other chromatin-associated signals.
Specialized PRC1 complexes such as PRC1.1, PRC1.3, PRC1.5, and PRC1.6 use different PCGF proteins and recruitment mechanisms to regulate H2AK119ub, chromatin organization, gene repression, development, and cellular identity.
KDM2B is an important chromatin regulator and targeting component of PRC1.1. Learn how its CXXC domain recognizes unmethylated CpG-rich DNA and contributes to Polycomb-mediated H2AK119ub, gene repression, development, stem-cell regulation, and epigenetic memory.
Polyhomeotic proteins PHC1, PHC2, and PHC3 are important components of PRC1 that help organize Polycomb-associated chromatin. Learn how PHC proteins contribute to PRC1 structure, H2AK119ub, chromatin architecture, gene repression, development, and epigenetic memory.
