RYBP and YAF2 are important components of non-canonical PRC1 complexes. Learn how they interact with RING1 proteins, regulate H2AK119ub, contribute to Polycomb-mediated gene repression, and function in chromatin organization, development, stem cells, and cancer.
CBX proteins are chromobox proteins that help canonical PRC1 recognize H3K27me3-marked chromatin. Learn how CBX2, CBX4, CBX6, CBX7, and CBX8 contribute to Polycomb recruitment, H2AK119ub, chromatin organization, development, stem-cell regulation, and gene repression.
PCGF proteins are key components of PRC1 that help determine the composition and function of different Polycomb complexes. Learn how PCGF1–PCGF6 interact with RING1 proteins to regulate H2AK119ub, chromatin, gene repression, development, stem cells, and cancer.
Canonical and non-canonical PRC1 are distinct Polycomb complexes with different subunits and recruitment mechanisms. Learn how they regulate H2AK119ub, chromatin organization, gene repression, development, stem cells, and epigenetic memory.
RING1A and RING1B are key E3 ubiquitin ligases within PRC1 that establish H2AK119ub, an important Polycomb-associated histone modification. Discover how these proteins regulate chromatin, gene repression, development, stem cells, and cellular identity.
EZH2 is the major catalytic methyltransferase component of PRC2 and plays a central role in Polycomb-mediated gene regulation. Learn how EZH2 establishes H3K27 methylation and contributes to development, stem-cell regulation, epigenetic memory, and cancer.
H2AK119ub is a major histone modification associated with PRC1-mediated Polycomb repression. Established primarily by RING1A and RING1B, it contributes to chromatin organization, transcriptional repression, development, stem-cell regulation, and cellular identity.
H3K27me3 is a major epigenetic histone modification associated with Polycomb-mediated gene repression. Established primarily by PRC2, it plays important roles in chromatin regulation, development, stem-cell biology, cellular differentiation, and disease.
PRC1 and PRC2 are major Polycomb Repressive Complexes that regulate gene expression through chromatin modification and organization. They play essential roles in development, differentiation, stem-cell biology, cellular identity, and epigenetic gene regulation.
COP1 and iron signaling converge through HY5, PIFs, FIT, iron transporters, protein stability, and hormone crosstalk to coordinate iron uptake, root development, photosynthesis, metabolism, and plant stress responses.
COP1 and potassium signaling converge through HY5, PIFs, potassium transporters, calcium signaling, protein stability, and hormone crosstalk to coordinate potassium uptake, root development, photosynthesis, and plant stress responses.
COP1 and phosphate signaling converge through HY5, PIFs, PHR1, SPX proteins, protein stability, and hormone crosstalk to coordinate phosphorus uptake, root development, metabolism, and plant growth.
COP1 and nitrogen signaling converge through HY5, PIFs, nitrate-responsive pathways, protein stability, and hormone crosstalk to coordinate nitrogen uptake, metabolism, root development, and plant growth.
COP1 and nutrient signaling converge through HY5, PIFs, protein stability, metabolism, and hormone crosstalk to coordinate nutrient acquisition, photosynthesis, plant growth, and environmental adaptation.
COP1 and cytokinin signaling converge through HY5, PIFs, ARR proteins, protein stability, and hormone crosstalk to coordinate plant growth, development, and environmental responses.
