Tag: Chromosomal passenger complex
Chromosomal Passenger Complex
The Chromosomal Passenger Complex (CPC) is a dynamic mitotic regulator composed of Aurora B, INCENP, Borealin and Survivin. It ensures accurate chromosome segregation, corrects spindle attachment errors and coordinates cytokinesis, making it essential for genomic stability and highly relevant in cancer biology.
Survivin
Survivin (BIRC5) is a tumour‑specific IAP that integrates apoptosis suppression with essential mitotic functions. As part of the chromosomal passenger complex, Survivin ensures proper chromosome segregation while stabilising anti‑apoptotic pathways, making it a central driver of tumour progression and therapy resistance.
Chromosomal Passenger Complex
The Chromosomal Passenger Complex (CPC) is a dynamic mitotic regulator composed of Aurora B, INCENP, Borealin and Survivin. It ensures accurate chromosome segregation, corrects spindle attachment errors and coordinates cytokinesis, making it essential for genomic stability and highly relevant in cancer biology.
Survivin
Survivin (BIRC5) is a tumour‑specific IAP that integrates apoptosis suppression with essential mitotic functions. As part of the chromosomal passenger complex, Survivin ensures proper chromosome segregation while stabilising anti‑apoptotic pathways, making it a central driver of tumour progression and therapy resistance.