Category: Lab Notes

List of Common Substrates of CDK1-Cyclin A and CDK2-Cyclin A

CDK1-cyclin A and CDK2-cyclin A share several substrates. MCMs (DNA replication)  Cdc7 (DNA replication)  Ribonucleotide reductase R2 (DNA replication)  pRb  …

List of Mammalian APC/C Substrates

Anillin  Aurora kinase A  Aurora kinase B  Cyclin A2  Cyclin B1  Cell division cycle-associated protein 3 (Also known as Tome-1) …

List of Cell Cycle Regulators Knockout Mice

Cyclin D1-/-: Viable, Reduced body size, Neurological abnormalities, Hypoplastic retinas Cyclin D2-/-: Viable, defects in B-cell proliferation, pancreatic beta cell…

List of G1-phase Regulators

Cyclin D family member Cyclin D1 Rb family members pRb/p105: pRb/p105 associates with the E2F activators and prevents them from…

List of Mitosis Regulators

Cyclin B1: Cyclin B1 interacts with CDK1 in late G2 and in M-phase and controls entry and progression through the…

List of Spindle Assembly Checkpoint (SAC) Regulators

INCENP (Inner centrosome protein) Aurora B Survivin Borealin Cdc20 BubR1 Bub3 Mad2 Emi1

List of CDK1 Substrates

Actopaxin Adenomatous polyposis coli Amphiphysin1 BARD1 BRCA2 Caldesmon Cdc7 Cdc20 Cdc25A Cdc25 C Cdh1 Cdk7 C/EBPβ CKII Dynein Dystrophin EF-1…

List of CDK2 Substrates

BARD1 B-Myb BRCA1 BRCA2 CBP/p300 Cdc6 Cdc7 Cdk7 Cdt1 C/EBPβ DP1 hHR6A HIRA Ku70 Marcks MCM2 MCM4 MyoD NPAT Npm…

List of CDK3 Substrates

ik3-1/Cables1 Activating transcription factor 1 (ATF1)

List of CDK5 Substrates

Amphiphysin1 Cables Disabled1 Doublecortin Munc18 Nudel p53 Pctaire1 Protein phosphatase inhibitor 1 PSD-95 Stat3 mSds3 SynapsinI Tyrosine hydroxylase

List of CDK7 Substrates

CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 p53 RARγ RNA pol II