Laboratory Notes
The following cell lines express relatively high levels of cyclin D1. MCF7 REFERENCES: Bienvenu et al., 2005. Transcriptional regulation by…
Wortmannin LY294002
Cas Noumber: 154447-36-6 Activities: Potent inhibitor of phosphoinositide 3-kinases (PI3Ks) Although it is a potent inhibitor of PI3K, it is…
Cyclin D1 has been shown to interact with STAT3. This interaction is not direct and is mediated by NcoA/SRC1a (Bienvenu…
HepG2 cells stably expressing Cyclin D1 show a reduced level of p21 expression (both mRNA and protein) as compared to…
Bienvenu and coworkers showed that stimulation of serum-starved HepG2 cells with IL6 induces p21 expression (Bienvenu et al., 2005). They…
Well-established oncogene Driver of tumors May confer resistance to chemotherapy Cyclin D overexpression, accumulation, and mislocalization have been reported in…
Cyclin-dependent kinases CDK4 and CDK6 (CDK4/6) play important roles in controlling the G1 phase progression, particularly passing the cells through…
As the name suggests, these kinases are dependent on their regulatory subunit “Cyclins” to function as a kinase. Cyclin-dependent kinases…
In humans, 20 Cyclin-Dependent Kinases have been reported. Cyclin-Dependent Kinase 1 (CDK1) Cyclin-Dependent Kinase 2 (CDK2) Cyclin-Dependent Kinase 3 (CDK3)…
Cyclin E1 is the first identified member of E-type cyclin. The other known member of E-type cyclin is cyclin E2….
Cyclin D-CDK4 and Cyclin D-CDK6 holoenzymes are reported to phosphorylate the following proteins: pRB p107 p130 Smad3 FOXM1 Cdt1
In contrast to other cell cycle phases, extracellular signaling from growth factors/mitogens is essential for G1 phase progression. These signaling…
Transcription factor Plays an important role in lineage determination Functions as a tumor suppressor Regulator of cell cycle and apoptosis…
D-type cyclins (or cyclin D)* are active in the G1 phase of the cell cycle. Their expression is induced by…
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