CagA physically interacts with E-cadherin and this interaction is independent of CagA tyrosine phosphorylation status (Murata-Kamiya et al., 2007).
Consequences of CagA-E-cadherin interaction
- The interaction between CagA and E-cadherin disrupts the interaction between E-cadherin and β-catenin, resulting in the relocalization of β-catenin from the plasma membrane at cell junctions to the cell cytoplasm and in the nucleus. (Murata-Kamiya et al., 2007)
- Nuclear β-catenin transactivates β-catenin-dependent genes such as cdx1 (Murata-Kamiya et al., 2007).
Murata-Kamiya et al., 2007. Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells. Oncogene. 26(32), 4617-4626. PMID-17237808; Full-Text Link: Nature