- The Cdk1-cyclin B1 kinase triggers mitosis in most eukaryotes.
- The complex between Cdk1-cyclin B1 functions as a kinase (serine-threonine kinase) where cyclin B1 is a regulatory subunit and Cdk1 is a catalytic subunit. It represents the classical M-phase promoting factor.
- Cdk1-cyclin B1 complex has been shown to be involved in cell cycle progression during M-phase. Its role in mitotic entry, progression, and mitotic exit is well established.
- Cdk1-cyclin B1 kinase activity is tightly regulated and is rapidly inactivated under situations of genomic damage and other conditions.
- After activation, cyclin B1- Cdk1 complex drive mitosis progression by phosphorylating many substrates which ultimately leads to many changes including cell rounding, nuclear envelope breakdown, chromosome condensation, centrosome splitting, and mitotic spindle formation.
- Substrates of cyclin B1-Cdk1 complex are localized in both cytoplasm and nucleus. They are :
- Components of the cytoskeleton microtubule
- Intermediate filament networks
- Golgi apparatus
- Nucleolus
- Nuclear pore complexes
- Nuclear lamins
- Anaphase-promoting complex/cyclosome
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