Cyclin D1 expression in Wildtype C57Bl/6J mice
- Immunohistochemistry (IHC) analysis using cyclin D1-specific antibodies reveals that cyclin D1 is widely expressed in different brain regions and is mostly present in the cell nucleus (intense staining in the nucleus (Koeller et al., 2008).
- Cyclin D1 protein is undetectable in the brain of C57Bl/6J mice by immunoblotting (Bhalla et al., 2014, Supplementary Figure 1).
- A very low level of Cyclin D1 transcripts can be detected by PCR-based analysis (Bhalla et al., 2014, Supplementary Figure 1).
REFERENCES:
- Bhalla et al., 2014. Cyclin D1 represses gluconeogenesis via inhibition of the transcriptional coactivator PGC1α. Diabetes. 63(10), 3266-78. PMID-24947365; Supplementary Table and Figures, Full-Text Links: diabetesjournals, PMC
- Koeller et al., 2008. Cyclin D1 in excitatory neurons of the adult brain enhances kainate-induced neurotoxicity. Neurobiol Dis. 31(2), 230-41. PMID-18585919; Full-Text Links: Sciencedirect, PMC
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