Cyclin E1

  • Cyclin E1 is the first identified member of E-type cyclin. The other known member of E-type cyclin is cyclin E2.
  • In humans, it is encoded by CCNE1 gene which localizes at 19q12 region.
  • Cyclin E1 contains 410 amino acids with a molecular weight of 47 kDa.
  • Several splice variants and isoforms of cyclin E1 have also been reported.
  • Both Cyclin E1 and cyclin E2 act as a regulatory unit of CDK2. The cyclin E-CDK2 holoenzymes drive G1/S phase transition by hyperphosphorylating Retinoblastoma family members (pRb, p107 and p130). They are also required for S phase progression.

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