• Cytokinesis is the last phase of the cell cycle that results in the generation of daughter cells.
  • Cytokinesis is precisely controlled in both time and space to ensure equal distribution of the genetic material between daughter cells.
  • Incomplete cytokinesis can be associated with developmental or pathological cell division programs leading to tetraploid progenies.
  • Specialized (incomplete) cytokinesis has been reported in hepatocytes during post-natal liver growth.
    • Elongation of anaphase cells does not occur.
    • No actin cytoskeleton rearrangement takes place.
    • The formation of a functional contractile actomyosin ring is not observed.
    • Impaired Rho kinase-dependent recruitment of myosin II to the cortex is reported.

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