Extracellular Matrix (ECM)

  • Extracellular matrix can be defined as a matrix associated with the extracellular part of cells (cell surface) in the tissue.
  • It is highly complex, dynamic in molecular composition but organized structure surrounding the cells (Cukierman et al., 2002).
  • It has many functions in addition to providing structural support to tissue and signal transduction in response to external cues.
  • ECM is secreted by the cells in a tissue.
  • Integrins, a family of heterodimeric, transmembrane cell surface receptors interact with ECM components, thereby important for the assembly of ECM around the cells.
  • ECM-integrin interaction regulates many cellular functions including cell migration, differentiation, proliferation and cell death.

Was this post helpful?

Author: admin

Leave a Reply

Your email address will not be published. Required fields are marked *