Glioma stem cells are a specific type of glioma cell population in glioma tumors that have neural stem cell-like features. These cells closely mimic the genotype, gene expression profile, and biology of their parental primary tumors (Lee et al., 2006).
- Ability to Self-renewal
- Expression of neural stem cell markers
- Resistance to radiation
Niche for glioma stem cells:
Glioma stem cells require a special environment that helps GSC to maintain its stem cell-like properties. Such an environment is provided by Niche, a specific region where GSCs are likely to reside.
A perivascular niche has been described for Glioma stem cells (Calabrese et al., 2007).
GBM recurrence is linked to GSC by many reports.
- Calabrese et al., 2007. A perivascular niche for brain tumor stem cells. Cancer Cell. 11(1), 69-82. PMID-17222791; Full-Text Link: cell
- Lee et al., 2006. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell. 9(5), 391-403. PMID-16697959; Full-Text Link: cell