Glioma Stem Cell (GSC)

Glioma stem cells are a specific type of glioma cell population in glioma tumors that have neural stem cell-like features. These cells closely mimic the genotype, gene expression profile, and biology of their parental primary tumors (Lee et al., 2006).


  • Ability to Self-renewal
  • Expression of neural stem cell markers
  • Resistance to radiation

Niche for glioma stem cells:
Glioma stem cells require a special environment that helps GSC to maintain its stem cell-like properties. Such an environment is provided by Niche, a specific region where GSCs are likely to reside.
A perivascular niche has been described for Glioma stem cells (Calabrese et al., 2007).

GBM recurrence is linked to GSC by many reports.


  • Calabrese et al., 2007. A perivascular niche for brain tumor stem cells. Cancer Cell. 11(1), 69-82. PMID-17222791; Full-Text Link: cell
  • Lee et al., 2006. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell. 9(5), 391-403. PMID-16697959; Full-Text Link: cell

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