PROTACs (PROteolysis TArgeting Chimeras)

Read the following reviews to know about PROTACs.

♦ Pettersson & Crews, 2019. PROteolysis TArgeting Chimeras (PROTACs) – Past, present and future. Drug Discov Today Technol . 2019 Apr;31:15-27. PMID-31200855; Full Text : Sciencedirect, PMC
♦  Girardini, et al., 2019. Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs. Bioorg Med Chem . 2019 Jun 15;27(12):2466-2479. PMID-30826187; Full Text – Sciencedirect, PMC
♦  Lu, et al., 2015. Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4. Chem Biol . 2015 Jun 18;22(6):755-63. PMID-26051217;  Full Text – Sciencedirect, PMC
♦ Chopra, et al., 2019. A critical evaluation of the approaches to targeted protein degradation for drug discovery. Drug Discov Today Technol. 31, 5-13. PMID-31200859;  Full Text – Sciencedirect, PMC
♦ Vogelmann et al., 2020. Proteolysis targeting chimeras (PROTACs) for epigenetics research. Curr Opin Chem Biol. 57, 8-16. PMID-32146413; Full Text – Sciencedirect
♦  Burslem et al., 2018. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell Chem Biol. 25(1), 67-77.e3. PMID-29129716; Full Text – Cell, PMC
♦  Naito et al., 2018. SNIPERs-Hijacking IAP activity to induce protein degradation. Drug Discov Today Technol . 2019 Apr;31:35-42. PMID-31200857; Full Text – Sciencedirect

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