The cell cycle is a highly regulated process. The transition from G2 phase to M phase is characterized by the activation of the CDK1-cyclin B1 complex. Cyclin B1 synthesis starts in the S phases and its level keeps rising during the G2 phase and it peaks in the mitosis. Cyclin B1 forms a complex with CDK1, however, this complex remains inactive due to inhibitory phosphorylation at Thr14 and Tyr15 by protein kinases such as Wee1 and Myt1. The complex remains inactive until the CDK1 is dephosphorylated at Thr 14 and Tyr 15 residue by Cdc25C phosphatase which happens at the end of the G2 phase. Activation of CDK1 marks the start of the M-phase.
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