- Integrin-mediated cell attachment to the extracellular matrix (ECM) has been shown to regulate the cell cycle.
- Cell cycle phases, the G1 phase and M-phase, require integrin-ECM interactions.
- G1 phase regulation by integrins
- Cyclin D1 and Cip/Kip family of CDK inhibitors are well-established targets of integrins during G1 phase progression.
- Several signaling pathways, FAK, Rho GTPases, and ERK, have been shown to be involved in the regulation of the G1 phase by integrins.
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