Role of Integrins in Cell Cycle Regulation

  • Integrin-mediated cell attachment to the extracellular matrix (ECM) has been shown to regulate the cell cycle.  
  • Cell cycle phases, the G1 phase and M-phase, require integrin-ECM interactions.  
  • G1 phase regulation by integrins  
    • Cyclin D1 and Cip/Kip family of CDK inhibitors are well-established targets of integrins during G1 phase progression.  
    • Several signaling pathways, FAK, Rho GTPases, and ERK, have been shown to be involved in the regulation of the G1 phase by integrins.

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