- An anthrapyrazolone
- Selective inhibitor of JNKs (Bennett et al., 2001)
- Reversible ATP- competitive inhibitor
- Often used to understand the role of JNKs-mediated signaling pathways in cellular processes (cell growth, differentiation, apoptosis)
ABBREVIATIONS:
- JNKs: c-Jun N-terminal kinases
REFERENCES:
- Bennett et al., 2001. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci U S A. 98(24):13681-6. PMID-11717429; Full-Text Links: PNAS, PMC
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