Cancer Stem Cell (CSC)

A specific type of cancer cell population in cancers that has adult stem cell-like features.


  • Ability to Self-renewal
  • Expression of adult stem cell markers
  • Resistance to radiation

Cancer stem cells have been reported in the following cancers:


  • Al-Hajj et al., 2003. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A. 100(7), 3983-8. PMID-12629218; Full Text Link: pnas, PMC
  • Lapidot et al., 1994. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 367(6464), 645-8. PMID-7509044; Full Text Link: nature 
  • Singh et al., 2004. Identification of human brain tumour initiating cells. Nature. 432(7015), 396-401. PMID-15549107; Full Text Link:  nature
  • Bonnet & Dick, 1997. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 3(7), 730-737. PMID-15549107; Full Text Link: nature 

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