A specific type of cancer cell population in cancers that has adult stem cell-like features.
Features:
- Ability to Self-renewal
- Expression of adult stem cell markers
- Resistance to radiation
Cancer stem cells have been reported in the following cancers:
- Brain tumors (Singh et al., 2004)
- Breast tumors (Al-Hajj et al., 2003)
- Acute myeloid leukemia (Lapidot et al., 1994; Bonnet & Dick, 1997)
REFERENCES:
- Al-Hajj et al., 2003. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A. 100(7), 3983-8. PMID-12629218; Full Text Link: pnas, PMC
- Lapidot et al., 1994. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 367(6464), 645-8. PMID-7509044; Full Text Link: nature
- Singh et al., 2004. Identification of human brain tumour initiating cells. Nature. 432(7015), 396-401. PMID-15549107; Full Text Link: nature
- Bonnet & Dick, 1997. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 3(7), 730-737. PMID-15549107; Full Text Link: nature
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