Cyclin B1 Subcellular Localization During Cell Cycle

  • During the G2 phase, cyclin B1 is localized in the cytoplasm.
  • Cyclin B1 accumulation on centrosome start in the mid-G2 phase. In late G2, the local concentration of cyclin B1 is highest at the centrosomes.
  • At the onset of mitosis, cyclin B1 accumulation starts in the nucleus.
  • During mitosis, after the nuclear membrane breaks down, it is present everywhere. Degradation of cyclin B1 starts at the beginning of the anaphase.

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