Chromosome Condensation During Mitosis

  • The first stage of mitosis
  • Early stages of chromosome condensation in prophase are reversible in many organisms.
  • The initiation of chromosome condensation in mitosis in many cell types can be monitored by light microscopy. 
  • The nuclear matrix becomes progressively granulated as the chromosome condenses. Condensing nuclear material appears as discrete granular patches which finally fuse and form a ribbon-like structure (the chromosome)
  • Cyclin A/CDK2 activity mediates the initiation of chromosome condensation.
  • Phosphorylation of histone H3 is reported to be required for chromosome condensation.
  • Hyperphosphorylation of the linker histone H1 has been observed during early prophase. However, this appears not to be required for chromosome condensation.
  • Aurora B protein kinase function in chromosome condensation by phosphorylating histone H3 on serine 10.

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