Cyclin D in Cancer

  • Well-established oncogene 
  • Driver of tumors 
  • May confer resistance to chemotherapy
  • Cyclin D overexpression, accumulation, and mislocalization have been reported in cancers in both solid and hematological malignancies
  • Cyclin D1 is the most commonly overexpressed in most cancers/tumors among D-type cyclins.
  • Not only Cyclin D-CDK4/6 holoenzymes but also D-type cyclins independently of their catalytic subunit have been shown to play a role in driving cancer progression.
  • Mutine models of oncogenesis have also supported the role of cyclin D in tumorigenesis.

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