Cyclin D1 expression in mice
- Cyclin D1 protein can be detected in the Liver by immunoblotting (Bhalla et al., 2014, Supplementary Figure 1).
- Cyclin D1 mRNA can also be detected by PCR-based analysis (Bhalla et al., 2014, Supplementary Figure 1).
- Compared to the intestine and spleen, the Liver expresses lower levels of cyclin D1 protein and transcript (Bhalla et al., 2014, Supplementary Figure 1). However, injury or partial hepatectomy induces a several-fold increase in cyclin D1 protein (Nelsen et al., 2001).
- Fasting suppresses the expression of cyclin D1 in the liver (Bhalla et al., 2014).
- Refeeding of fasted mice induces cyclin D1 expression in the liver (Bhalla et al., 2014).
REFERENCES:
- Bhalla et al., 2014. Cyclin D1 represses gluconeogenesis via inhibition of the transcriptional coactivator PGC1α. Diabetes. 63(10), 3266-78. PMID-24947365; Supplementary Table and Figures, Full-Text Links: diabetesjournals, PMC
- Nelsen et al., 2001. Transient expression of cyclin D1 is sufficient to promote hepatocyte replication and liver growth in vivo. Cancer Res. 61(23), 8564-8. PMID-11731443; Full-Text Links: aacrjournals, silverchair
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