A gene can be easily delivered using Adenovirus to the liver hepatocytes of mice.
- Nelsen and coworkers injected CsCl-purified adenoviruses encoding mammalian cyclin D1 via the tail vein of mice and showed efficient expression of cyclin D1 in liver hepatocytes (Nelsen et al., 2001).
REFERENCES:
Nelsen et al., 2001. Transient expression of cyclin D1 is sufficient to promote hepatocyte replication and liver growth in vivo. Cancer Res. 61(23), 8564-8. PMID-11731443; Full-Text Links: aacrjournals, silverchair
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