- Rod-shaped, gram negative bacteria
- Extensively used in the research and biotech and pharmaceutical industry
- Most E. coli strains are harmless, some are pathogenic to humans.
- Harmless strains of E. coli are present in the lower intestine of humans and other mammals and benefit their hosts by producing vitamin K2 and preventing colonization of pathogenic bacteria.
- Most laboratory strains of E. coli are derived from K-12 strain.
Advantages and applications:
- Whole genome is sequenced
- Easy manipulation
- Well known genetics
- Harmless to humans (laboratory strains)
- High growth rate with minimal growth requirements (can grow rapidly when provided with simple media containing carbon and nitrogen and some trace elements
- Suitable to answer fundamental questions in biology (our early knowledge on DNA replication, transcription, translation, gene regulation, restriction enzymes were mostly based work on E. coli)
- Suitable for production of pharmaceutical compounds for human use (e.g., production of recombinant insulin)
Was this post helpful?
Let us know if you liked the post. That’s the only way we can improve.