Escherichia coli

Overview

  • Rod-shaped, gram negative bacteria
  • Extensively used in the research and biotech and pharmaceutical industry
  • Most E. coli strains are harmless, some are pathogenic to humans.
  • Harmless strains of E. coli are present in the lower intestine of humans and other mammals and benefit their hosts by producing vitamin K2 and preventing colonization of pathogenic bacteria.
  • Most laboratory strains of E. coli are derived from K-12 strain.

Advantages and applications:

  • Whole genome is sequenced
  • Easy manipulation
  • Well known genetics
  • Harmless to humans (laboratory strains)
  • High growth rate with minimal growth requirements (can grow rapidly when provided with simple media containing carbon and nitrogen and some trace elements
  • Suitable to answer fundamental questions in biology (our early knowledge on DNA replication, transcription, translation, gene regulation, restriction enzymes were mostly based work on E. coli)
  • Suitable for production of pharmaceutical compounds for human use (e.g., production of recombinant insulin)

Was this post helpful?

Author: admin

Leave a Reply

Your email address will not be published.