ExpSup: CagA Induces β-catenin Relocalization from Cell Membrane to Nucleus in Tyrosine-phosphorylation Independent Manner

Murata-Kamiya et al., 2007 showed that β-catenin is localized in the plasma membrane at cell-cell junctions in the MKN-28 cell line using immunocytochemistry. Upon cagA ectopic expression (wild-type or phospho-resistant mutant), β-catenin is also seen in the cytoplasm and in the nucleus. 

Method: Immunocytochemistry
Cell line: MKN-28 stably expressing wild-type and phospho-resistant CagA


Murata-Kamiya et al., 2007. Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells. Oncogene. 26(32), 4617-4626. PMID-17237808; Full Text Links: Nature

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