ExpSup: IL6 Induces p21 Transcription in Serum-starved HepG2 Cells

Bienvenu and coworkers analyzed the expression of p21 in serum-starved HepG2 cells upon IL6 stimulation. HepG2 Cells were serum starved for 2 days and then treated with IL6 (10 ng/ml) for 4 h. Total RNA was isolated and the p21 level was analyzed by northern blotting. They detected an increase in p21 transcripts (Bienvenu et al., 2005). 

Bienvenu et al., 2005. Transcriptional regulation by a DNA-associated form of cyclin D1.  Mol Biol Cell. 16(4), 1850-8. PMID-15659654; Full-Text Links: molbiolcell, PMC1073666

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