ExpSup: T241 Tumor Cells do not Form Invasive Metastatic Tumors in Zebrafish Xenograft Model

Note: The following study has analyzed tumor morphology in the Zebrafish Xenograft Model following the implantation of T241 tumor cells. For more details and accuracy, please read the recommended references carefully.

  • Lee and coworkers implanted T241 tumor cells into the perivitelline cavity of 48 h post-fertilized fli1:EGFP zebrafish embryos and studied the tumor morphology. They observed most tumor cells restricted to the primary site after 3 days post-implantation.
    • Animal: fli1:EGFP zebrafish
    • Cell line: DiI-labeled T241 tumor cell line


  • DiI: 1,1′-Dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate
  • EGFP: Enhanced Green Fluorescent Protein
  • fli1:EGFP: Zebrafish expressing EGFP under the fli1 promoter. In these zebrafishes, all blood vessels are labeled with EGFP


Lee et al., 2009. Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model. Proc Natl Acad Sci U S A. 106 (46), 19485-19490. PMID-19887629; Full-Text Links: PNAS, PMC

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