Helicobacter pylori

OrganismHelicobacter pylori (Formerly known as Campylobacter pylori)
Organism typeBacteria
Discovered byWarren & Marshall (1983)
Ecological niche (in humans)Stomach (gastric epithelium/Mucous layer)
Unique featureSurvival in the harsh acidic conditions (pH < 2) of the stomach
Infected people
  • ≈ 50% human population (globally)
  • Incident rates vary in different regions of the world
Classification (disease)Pathogenic
Diseases (In host – Human)
  • Asymptomatic (most infected population)
  • Chronic gastritis
  • Peptic ulcers
  • Gastric cancer (adenocarcinoma)
  • Mucosa-associated lymphoid tissue (MALT) lymphoma
TransmissionNot exactly known (Predicted)fecal-oral or oral-oral route Poor hygiene and crowded conditions
Gram stainingGram-negative
Size≈ 3 µm long
Culture environmentMicroaerophilic
  • ≈ 50% of the world’s population is infected with Helicobacter pylori. A minority of the infected population can develop diseases such as chronic gastritis, peptic ulcers, gastric cancer (adenocarcinoma), and mucosa-associated lymphoid tissue (MALT) lymphoma
  • It usually colonizes the human gastric (stomach) epithelium luminal surface

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