The interaction of glioma cells with blood vessels has a high impact on glioma development, therefore has been considered as a potential target for developing novel therapies against glioma.
Association of glioma cells with preexisting vessels is called vessel co-option. Vessel co-option has been reported at early stages of tumor development and it continues throughout the tumor progression and development. It is linked to diffuse invasive growth of glioblastoma and ineffectiveness of anti-angiogenic therapy that targets neoangeogenesis.
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