List of Mitosis Regulators

  • Cyclin B1: Cyclin B1 interacts with CDK1 in late G2 and in M-phase and controls entry and progression through the M-phase
  • Cdk-activating kinase (CAK): CAK interact CDK1 at late G2 phase and regulate CDK1 activity by phosphorylating it at Thr161 
  • Plk1: Plk1 phosphorylate CDK1 at Ser147 in the late G2 phase, which promote nuclear translocation of Cdk1
  • Cdc25 phosphatases (Cdc25B and Cdc25C): Dephosphorylation of Thr14 and Tyr15 at late G2 phase is done by Cdc25B and Cdc25C phosphatases

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