- Cyclin B1: Cyclin B1 interacts with CDK1 in late G2 and in M-phase and controls entry and progression through the M-phase
- Cdk-activating kinase (CAK): CAK interact CDK1 at late G2 phase and regulate CDK1 activity by phosphorylating it at Thr161
- Plk1: Plk1 phosphorylate CDK1 at Ser147 in the late G2 phase, which promote nuclear translocation of Cdk1
- Cdc25 phosphatases (Cdc25B and Cdc25C): Dephosphorylation of Thr14 and Tyr15 at late G2 phase is done by Cdc25B and Cdc25C phosphatases
