List of G1-phase Regulators

  • Cyclin D family member
    • Cyclin D1
  • Rb family members
    • pRb/p105: pRb/p105 associates with the E2F activators and prevents them from stimulating the transcriptional activity of the promoters
    • pRb/p107
    • pRb2/p130: pRb2/p130 forms a complex with E2F4 (also with E2F5), which binds to promoters of genes required for S-phase entry, recruits a number of chromatin remodeling factors, such as SWI/SNF and HDAC thereby repress transcription
  • INK4 family
    • p15Ink4b
    • p16Ink4a
    • p18Ink4c
    • p19Ink4d
  • Cip/Kip family
    • p21
    • p27
    • p57
  • E2F family members
    • E2F1
    • E2F2
    • E2F3a
    • E2F3b
    • E2F4
    • E2F5
    • E2F6
    • E2F7a
    • E2F7b
  • Cyclin E
  • Histone deacetylase (HDAC)

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