- Primary brain tumor
- Most common malignant pediatric brain tumor
- Classified as Malignant grade IV tumor
- Fast-growing tumor
- Mostly occurs in children, but can also be found in adults
- Spreads to other parts of CNS through mainly cerebrospinal fluids
- Symptoms: Blurred and double vision, Confusion, Extreme sleepiness, Headaches, Nausea, Seizures, Vomiting
- Genetic changes: loss of chromosome 10 (Reardon et al., 1997)
Medulloblastomas are classified into 4 subtypes based on genomic analysis:
- WNT-activated
- SHH-activated
- group 3 (non-WNT / non-SHH)
- group 4 (non-WNT / non-SHH)
REFERENCES
Reardon et al., 1997. Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization. Cancer Res. 57(18), 4042-4047. PMID-9307291; Full-Text Link: aacrjournals
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