- p27, a member of cyclin-dependent kinase inhibitors (CKIs), is up-regulated in the suspension culture of most cell lines including cancer cell lines.
- Upregulated p27 suppresses anchorage independent growth.
- p27 is expressed at high level upon suspension culture of primary untransformed fibroblast.
- Reduced level of p27 expression in suspension culture of Ras transformed cells is associated with their ability to promote anchorage independent growth.
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