Note: The following study has analyzed Hypoxia-Induced Neovascularization in Zebrafish Xenograft Model. For more details and accuracy, please read the recommended references carefully.
- Lee and coworkers implanted transplanted T241 fibrosarcoma tumor cells into the perivitelline cavity of 48 h post-fertilized fli1:EGFP zebrafish embryos and studied the Neovascularization of the implanted sites under hypoxic conditions. They observed significantly more Neovascularization at implantation sites under hypoxic conditions compared to normoxic conditions.
- Animal: fli1:EGFP zebrafish
- Cell line: DiI-labeled T241 fibrosarcoma tumor cell line
- Lee and coworkers implanted LLC tumor cells into the perivitelline cavity of 48 h post-fertilized fli1:EGFP zebrafish embryos and studied the Neovascularization of the implanted sites under hypoxic conditions. They observed significantly more Neovascularization at implantation sites
- Animal: fli1:EGFP zebrafish
- Cell line: DiI-labeled LLC tumor cell line
ABBREVIATIONS
- DiI: 1,1′-Dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate
- EGFP: Enhanced Green Fluorescent Protein
- fli1:EGFP: Zebrafish expressing EGFP under the fli1 promoter. In these zebrafishes, all blood vessels are labeled with EGFP
- LLC: Lewis Lung Carcinoma
REFERENCES
Lee et al., 2009. Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model. Proc Natl Acad Sci U S A. 106 (46), 19485-19490. PMID-19887629; Full-Text Links: PNAS, PMC
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