- The nuclear membrane acts as a barrier between the cytoplasm and the nucleoplasm.
- Under certain situations, the nuclear membrane is damaged, leading to the exchange of cytoplasmic and nucleoplasmic content.
- The loss of nuclear membrane integrity due to damage can cause genomic DNA damage and cancer.
- Depending on how the damage is induced, Nuclear membrane damage can be of the following types:
- Spontaneous damage
- Damage induced by mechanical stress
- In addition, the nuclear membrane is disintegrated during mitosis, a highly controlled cell cycle phase.
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