Nuclear Membrane Rupture

  • The nuclear membrane acts as a barrier between the cytoplasm and the nucleoplasm.
  • Under certain situations, the nuclear membrane is damaged, leading to the exchange of cytoplasmic and nucleoplasmic content.
  • The loss of nuclear membrane integrity due to damage can cause genomic DNA damage and cancer.
  • Depending on how the damage is induced, Nuclear membrane damage can be of the following types:
    • Spontaneous damage
    • Damage induced by mechanical stress
  • In addition, the nuclear membrane is disintegrated during mitosis, a highly controlled cell cycle phase.

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