Tag: topoisomerase
Topoisomerases in Viral Replication
Viruses rely heavily on topoisomerases for successful replication, though their dependence on these enzymes varies based on viral genome type…
Topoisomerases and Neurodegenerative Diseases
Topoisomerases play significant roles in neuronal function and their dysfunction has been increasingly linked to various neurodegenerative conditions. Type IB…
Topoisomerases and Antibiotic Resistance
Topoisomerases are critical targets for antibiotics, and their role in antibiotic resistance represents a significant clinical challenge. DNA gyrase and…
Topoisomerases in Chromosome Condensation
Topoisomerases play a crucial role in chromosome condensation, a complex process that transforms loosely organized interphase chromatin into highly compact…
Topoisomerases in Transcription
Topoisomerases play a vital role in transcription by regulating DNA supercoiling and ensuring smooth progression of RNA polymerase along the…
Topoisomerase Inhibitors
Topoisomerase inhibitors are a critical class of chemotherapeutic agents that target enzymes essential for maintaining DNA topology during key cellular…
Evolution of Topoisomerases
Topoisomerases are essential enzymes that have evolved to solve the topological problems inherent in DNA metabolism. These enzymes emerged early…
Topoisomerases as Drug Targets
Topoisomerases are well-established drug targets, particularly in cancer therapy, due to their essential roles in DNA metabolism and the maintenance…
Topoisomerases in DNA Replication
Topoisomerases play a crucial role in DNA replication by managing the topological stress that arises as the DNA double helix…
Topoisomerases in Cancer
Topoisomerases are essential enzymes that regulate the overwinding and tangling of DNA that occur during processes such as replication, transcription,…
Type I Topoisomerases Vs Type II Topoisomerases
Criteria Type I Topoisomerases Type II Topoisomerases Remarks Strand Cleavage Cleave one strand of the DNA duplex Cleave both strands…
Topoisomerase
Topoisomerases are remarkable enzymes that play a fundamental role in managing DNA topology within cells. These specialized proteins help solve…