Category: Database: Gene/Protein
SHP-1 (Src Homology Region 2-containing Protein Tyrosine Phosphatase-1)
SHP-1 (Src homology region 2-containing protein tyrosine phosphatase-1), encoded by the PTPN6 gene, is a cytoplasmic protein tyrosine phosphatase predominantly…
SHP-2 (Src Homology Region 2-containing Protein Tyrosine Phosphatase-2)
SHP-2 (Src homology region 2-containing protein tyrosine phosphatase-2), encoded by the PTPN11 gene, is a widely expressed protein tyrosine phosphatase…
Hepatocyte Growth Factor (HGF)
Hepatocyte Growth Factor (HGF), also known as scatter factor, is a multifunctional cytokine that plays crucial roles in cell proliferation,…
Gelatinase
Gelatinases, a subgroup of matrix metalloproteinases (MMPs), primarily include MMP-2 (gelatinase A) and MMP-9 (gelatinase B). These enzymes are specialized…
Selectin
Selectins are a family of adhesion molecules that play crucial roles in cell-cell interactions, particularly in the initial steps of…
Glycoprotein
Glycoproteins are proteins that are covalently bonded to carbohydrate chains (glycans), forming one of the most abundant and functionally diverse…
Cadherin
Cadherins are a superfamily of calcium-dependent cell adhesion molecules that mediate homophilic interactions between adjacent cells. As key components of…
Laminin
Laminins are a family of large, multidomain glycoproteins that are critical components of the basement membrane, a specialized sheet-like form…
Fibronectin
Fibronectin is a high-molecular-weight glycoprotein of the extracellular matrix (ECM) that plays a crucial role in cell adhesion, migration, growth,…
β-Catenin
β-Catenin is a multifunctional protein that plays central roles in both cell–cell adhesion and gene transcription. It is encoded by…
CagA Structure
Cytotoxin-associated gene A (CagA), encoded by Helicobacter pylori, is one of the bacterium’s most potent virulence factors. It plays a…
CagA Types Based on EPIYA Motifs
The CagA protein of Helicobacter pylori is classified into two main types based on the arrangement of EPIYA motifs: Western-type…
Phosphorylation-Independent CagA Signaling in Host Cell Transformation
The Helicobacter pylori CagA protein is a multifunctional bacterial effector and a central virulence determinant associated with gastric diseases, including…
Mucins
Mucins are a family of high-molecular-weight, heavily glycosylated proteins that play a crucial role in protecting and lubricating epithelial surfaces…
Topic: Cytotoxin-Associated Gene A (CagA)
CagA (Cytotoxin-Associated Gene A) CagA Types Based on EPIYA Motifs EPIYA Motifs CagA – PAR1b/MARK2 Interaction CagA/E-cadherin interaction Phosphorylation-Independent CagA…