Category: Lab Notes: Pharmaceutical Industry
Diagnostic Biomarker
Diagnostic biomarkers are measurable biological indicators used to identify the presence of a specific disease or pathological condition in an…
Monolix
Monolix represents a modern, sophisticated software platform designed for pharmacometric analysis, specifically focusing on nonlinear mixed-effects modeling. Developed by Lixoft,…
NONMEM (NONlinear Mixed Effects Modeling)
NONMEM represents a specialized software platform and methodology that has become the gold standard in population pharmacokinetic/pharmacodynamic (PK/PD) modeling and…
Therapeutic Drug Monitoring
Therapeutic Drug Monitoring (TDM) represents a specialized clinical practice that measures specific drug concentrations in a patient’s blood at designated…
Cytochrome P450 Polymorphisms
Cytochrome P450 (CYP450) polymorphisms represent genetic variations in the enzymes responsible for drug metabolism, significantly impacting how individuals respond to…
ADME Principle
The ADME principle represents the four fundamental processes that describe a drug’s journey through the body: Absorption, Distribution, Metabolism, and…
Pharmacokinetics
Pharmacokinetics is the study of how the body processes drugs over time, encompassing the complete journey of a drug from…
Pharmacodynamics
Pharmacodynamics is the study of how drugs affect the body and their mechanisms of action at the molecular, cellular, and…
Bayesian Forecasting in Precision Dosing
Bayesian forecasting is a statistical method rooted in Bayes’ theorem, which allows for the updating of predictions as new data…
Model-Informed Precision Dosing
Model-Informed Precision Dosing (MIPD) is an advanced clinical approach that uses mathematical and computational models to individualize drug dosing based…
Dimethyl Sulfoxide (DMSO) in Drug Delivery
Dimethyl sulfoxide (DMSO) is a small, polar, aprotic solvent known for its unique physicochemical properties, which make it an effective…
Amphotericin B in Combination Therapy
Amphotericin B has long been regarded as a cornerstone antifungal agent due to its broad-spectrum activity against a wide range…
Topical Use of Amphotericin B
Amphotericin B, a polyene macrolide antibiotic derived from Streptomyces nodosus, is well-known for its potent antifungal activity and is traditionally…
ICH Q9
ICH Q9, titled “Quality Risk Management”, is a guideline issued by the International Council for Harmonisation (ICH) that provides a…
ICH Q10
ICH Q10, titled “Pharmaceutical Quality System”, is a guideline developed by the International Council for Harmonisation (ICH) that provides a…