Tag: Membrane trafficking
RNF115 (RING Finger Protein 115)
RNF115 (BCA2) is a dual RING/U‑box E3 ubiquitin ligase that regulates membrane trafficking, innate immunity and antiviral defence. By ubiquitinating BST‑2/Tetherin, Rab7‑associated endosomal proteins and EGFR, RNF115 influences receptor turnover, immune signalling and cancer progression, making it a key regulator of cellular homeostasis.
Membrane Trafficking
Membrane trafficking is the vesicular transport system that moves proteins and lipids between organelles, enabling secretion, endocytosis and cellular signalling. Regulated by Rab GTPases, coat proteins and SNARE complexes, these pathways maintain organelle identity, nutrient uptake and membrane turnover, forming a central mechanism of eukaryotic cell organisation.
RNF115 (RING Finger Protein 115)
RNF115 (BCA2) is a dual RING/U‑box E3 ubiquitin ligase that regulates membrane trafficking, innate immunity and antiviral defence. By ubiquitinating BST‑2/Tetherin, Rab7‑associated endosomal proteins and EGFR, RNF115 influences receptor turnover, immune signalling and cancer progression, making it a key regulator of cellular homeostasis.
Membrane Trafficking
Membrane trafficking is the vesicular transport system that moves proteins and lipids between organelles, enabling secretion, endocytosis and cellular signalling. Regulated by Rab GTPases, coat proteins and SNARE complexes, these pathways maintain organelle identity, nutrient uptake and membrane turnover, forming a central mechanism of eukaryotic cell organisation.