Category: Lab Notes: Cell Biology
COP1 Subcellular Localization in Mammalian Cells
In mammalian cells, COP1 is a nucleocytoplasmic shuttling protein, but unlike in plants, its regulation is primarily linked to growth…
COP1 Subcellular Localization in Plant Cells
In plants, COP1 exhibits a dynamic subcellular localization that is tightly controlled by light conditions, making it a central regulator…
COP1 Subcellular Localization
COP1 is an evolutionarily conserved E3 ubiquitin ligase that plays a central role in light signaling in plants and in…
Post-Translational Modifications in Proteolysis
Post-translational modifications (PTMs) in proteolysis represent a crucial layer of regulation in protein quality control and turnover, linking chemical modifications…
Ubiquitin–Proteasome System
The ubiquitin–proteasome system (UPS) is the primary pathway for targeted protein degradation in eukaryotic cells, ensuring that damaged, misfolded, or…
Microtubule Organizing Center
The Microtubule Organizing Center (MTOC) is a specialized cellular structure that serves as the primary site for microtubule nucleation and…
CRM1-Mediated Nuclear Export
CRM1, also known as exportin 1 or XPO1, is a key nuclear export receptor that mediates the transport of a…
Cell Immortalization
Cell immortalization is a biological process where normal cells, which typically have a limited lifespan, are transformed into cells that…
HeLa Cells and the Development of the Polio Vaccine
HeLa cells, derived from the cervical cancer of Henrietta Lacks in 1951 without her consent, have played a pivotal role…
Cell Immortalization – Timeline of Key Events
Cell immortalization is defined as the process by which cells acquire the capacity to proliferate indefinitely, overcoming the normal replicative…
Advantages and Limitations of Immortalized Cell Lines
Immortalized cell lines are powerful tools for research due to their scalability, ease of use, and reproducibility, but their artificial…
Nucleolar Organizer Region
The nucleolar organizer region (NOR) is a chromosomal locus that plays a central role in the formation of the nucleolus…
Post-Mitotic Nucleolar Reassembly at rDNA Clusters
As cells complete mitosis and enter the early G1 phase, one of the first and most essential events in nuclear…
TRPP Channel
The Transient Receptor Potential Polycystin (TRPP) subfamily is a group of ion channels within the broader TRP channel superfamily, best…
TRPML Channel
The Transient Receptor Potential Mucolipin (TRPML) subfamily is a distinct group within the TRP channel superfamily, primarily localized to intracellular…