Orthology inference identifies evolutionary relationships between genes using sequence similarity, gene families, phylogenetics, synteny, and computational methods. Learn the major approaches and their limitations.
Reciprocal Best BLAST Hits (RBH) provide a simple approach for identifying candidate orthologs between organisms. Learn how reciprocal BLAST works, how to interpret results, and why RBH does not always prove orthology.
Paralogs are homologous genes that arise through gene duplication. Learn how duplicated genes evolve, how paralogs differ from orthologs, and why they are important in comparative genomics and gene-family evolution.
Orthology inference identifies evolutionary relationships between genes using sequence similarity, gene families, phylogenetics, synteny, and computational methods. Learn the major approaches and their limitations.
Reciprocal Best BLAST Hits (RBH) provide a simple approach for identifying candidate orthologs between organisms. Learn how reciprocal BLAST works, how to interpret results, and why RBH does not always prove orthology.
Paralogs are homologous genes that arise through gene duplication. Learn how duplicated genes evolve, how paralogs differ from orthologs, and why they are important in comparative genomics and gene-family evolution.
