- Zinc bisglycinate is a chelated form of zinc in which a zinc ion is bound to two molecules of the amino acid glycine. It is often represented by the formula Zn(C₂H₄NO₂)₂ and appears as a white to off-white powder that is soluble in water. This form of zinc is known for its exceptionally high bioavailability and gentle effect on the digestive system, making it a preferred option in nutritional supplementation, particularly for individuals with sensitive stomachs or absorption difficulties.
- The chelation of zinc with glycine, a non-essential amino acid, enhances its stability and absorption in the gastrointestinal tract. In this structure, the glycine molecules act as ligands, shielding the zinc ion from interactions with dietary inhibitors like phytates, which are commonly found in grains and legumes and can hinder mineral absorption. As a result, zinc bisglycinate is absorbed more efficiently than many traditional inorganic zinc salts such as zinc oxide or zinc sulfate. This makes it particularly valuable for people who are zinc deficient or have increased zinc needs due to stress, illness, or dietary restrictions.
- Zinc plays a critical role in over 300 enzymatic processes, including those related to immune function, cellular repair, DNA synthesis, hormone regulation, and antioxidant defense. Zinc bisglycinate is often included in high-quality multivitamin formulations and standalone supplements, especially in products marketed for immune health, skin and hair care, reproductive health, and cognitive function. It is also suitable for use in prenatal vitamins, pediatric nutrition, and products for older adults due to its superior tolerance and absorption profile.
- One of the key benefits of zinc bisglycinate is its digestive friendliness. In contrast to some zinc salts like zinc sulfate, which are known to cause stomach upset or nausea, zinc bisglycinate is usually well tolerated even on an empty stomach. This makes it ideal for individuals with gastrointestinal sensitivities or those who need long-term zinc supplementation.
- Zinc bisglycinate is generally safe when used within recommended doses, but as with any form of zinc, excessive intake can result in side effects such as nausea, vomiting, and interference with copper absorption. Prolonged high-dose zinc supplementation can lead to copper deficiency, which may impair immune function and cause anemia. For this reason, balanced formulations may also include copper to maintain mineral equilibrium.
