- Omeprazole is a proton pump inhibitor (PPI) that reduces stomach acid production by blocking the H+/K+ ATPase enzyme in the parietal cells of the stomach lining. This irreversible inhibition of the gastric proton pump prevents the final step of acid secretion, allowing injured tissue to heal and protecting from further damage.
- The medication is widely prescribed for treating various digestive disorders, including gastroesophageal reflux disease (GERD), duodenal and gastric ulcers, and erosive esophagitis. By suppressing acid production, it effectively manages symptoms such as heartburn, regurgitation, and difficulty swallowing.
- Omeprazole is also a key component in combination therapy for Helicobacter pylori (H. pylori) eradication, typically combined with antibiotics like amoxicillin and clarithromycin. The reduced stomach acidity created by omeprazole enhances the antibiotics’ effectiveness, leading to improved infection clearance rates.
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