- Nucleophosmin (NPM) plays a significant role in cell transformation, particularly through its interaction with c-Myc.
- In their 2008 study, Li and coworkers (Li et al., 2008) demonstrated that p53−/−/ARF−/− double knockout mouse embryo fibroblasts (MEFs) undergo cell transformation when both activated c-Myc and nucleophosmin are expressed. This fibroblast cell line exhibits increased cell density and the ability to grow in soft agar, a hallmark of transformation, upon the expression of c-Myc and NPM. Notably, downregulation of NPM reverses these effects. However, NPM alone is insufficient to induce cell transformation.
Was this post helpful?
Let us know if you liked the post. That’s the only way we can improve.
