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Heterologous Expression System
Heterologous expression systems are experimental platforms used to express genes or proteins in a host organism that is different from…
Heterologous Expression
Heterologous expression refers to the production of a gene product — typically a protein — in a host organism, cell…
Ectopic Expression
Ectopic expression refers to the abnormal or unintended activation of a gene in a cell type, tissue, or developmental stage…
SHP-1 Expression in AGS Cell Line
SHP-1 expression in the AGS cell line appears to be minimal under normal conditions (Higashi et al., 2002, Kim et…
Ref: Epigenetic regulation and anti-tumorigenic effects of SH2-containing protein tyrosine phosphatase 1 (SHP1) in human gastric cancer cells.
Joo et al., 2016. Epigenetic regulation and anti-tumorigenic effects of SH2-containing protein tyrosine phosphatase 1 (SHP1) in human gastric cancer…
Ref: Inhibition of STAT3 in gastric cancer: role of pantoprazole as SHP-1 inducer.
Koh et al., 2018. Inhibition of STAT3 in gastric cancer: role of pantoprazole as SHP-1 inducer. Cell Biosci. 8, 50….
Ref: Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites.
Higashi et al., 2002. Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine…
Ref: Arsenic trioxide attenuates STAT-3 activity and epithelial-mesenchymal transition through induction of SHP-1 in gastric cancer cells.
Kim et al., 2018. Arsenic trioxide attenuates STAT-3 activity and epithelial-mesenchymal transition through induction of SHP-1 in gastric cancer cells….
SHP-1 (Src Homology Region 2-containing Protein Tyrosine Phosphatase-1)
SHP-1 (Src homology region 2-containing protein tyrosine phosphatase-1), encoded by the PTPN6 gene, is a cytoplasmic protein tyrosine phosphatase predominantly…
SHP-2 (Src Homology Region 2-containing Protein Tyrosine Phosphatase-2)
SHP-2 (Src homology region 2-containing protein tyrosine phosphatase-2), encoded by the PTPN11 gene, is a widely expressed protein tyrosine phosphatase…
Hepatocyte Growth Factor (HGF)
Hepatocyte Growth Factor (HGF), also known as scatter factor, is a multifunctional cytokine that plays crucial roles in cell proliferation,…
ExpSup: CagA Undergoes Tyrosine Phosphorylation in Non-Gastric COS-7 Cells
Background: CagA undergoes tyrosine phosphorylation in gastric epithelial cell lines, such as the AGS cell line. Interestingly, it has also…
ExpSup: Membrane Localization of CagA is Independent of Tyrosine Phosphorylation
The following experimental approaches support the notion that “Membrane localization of CagA is independent of tyrosine phosphorylation”. Immunofluorescence analysis of…
Ref: SHP-2 Tyrosine Phosphatase as an Intracellular Target of Helicobacter pylori CagA Protein.
Higashi et al., 2002. SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science. 295(5555), 683-686. PMID-11743164;…
Mucosal-Associated Lymphoid Tissue (MALT)
Mucosal-associated lymphoid tissue (MALT) is a specialized component of the immune system located at mucosal surfaces throughout the body. These…