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Caseinolytic activity
Caseinolytic activity refers to the ability of proteases to degrade casein, a milk-derived phosphoprotein. This property is commonly used to…
Zymography
Zymography is a sensitive, semi-quantitative electrophoretic technique used to detect and analyze the enzymatic activity of proteases, especially matrix metalloproteinases…
Gelatinase
Gelatinases, a subgroup of matrix metalloproteinases (MMPs), primarily include MMP-2 (gelatinase A) and MMP-9 (gelatinase B). These enzymes are specialized…
MicroRNAs (miRNAs) in Epithelial-to-Mesenchymal Transition (EMT)
MicroRNAs (miRNAs) are small non-coding RNAs, typically 20–24 nucleotides in length, that play a key role in the post-transcriptional regulation…
Post-Translational Control in Epithelial-to-Mesenchymal Transition (EMT)
Post-translational control plays a crucial role in modulating the dynamics and reversibility of epithelial-to-mesenchymal transition (EMT) by altering the stability,…
Transcriptional Regulation in Epithelial-to-Mesenchymal Transition (EMT)
Transcriptional regulation is a central mechanism in controlling epithelial-to-mesenchymal transition (EMT), orchestrating the complex gene expression changes that allow epithelial…
Mutant
In genetics, a mutant is any organism, cell, or virus that has undergone a mutation—a change in its DNA sequence…
Isogenic Mutant
Isogenic mutants are genetically engineered organisms or cell lines that are identical to their parental (wild-type) counterparts in every aspect…
Snail Transcription Factor in Epithelial-to-Mesenchymal Transition (EMT)
Snail is a critical transcription factor involved in the process of Epithelial-to-Mesenchymal Transition (EMT), which is essential for various physiological…
Tight Junctions in Epithelial-to-Mesenchymal Transition (EMT)
Tight junctions are specialized cell-cell adhesion structures that play a fundamental role in maintaining the polarity and integrity of epithelial…
Fibronectin in Epithelial-to-Mesenchymal Transition (EMT)
Fibronectin is a large, extracellular matrix (ECM) glycoprotein that plays a central role in epithelial-to-mesenchymal transition (EMT) by facilitating cell-matrix…
N-cadherin in Epithelial-to-Mesenchymal Transition (EMT)
N-cadherin, a type of cadherin that mediates calcium-dependent cell-cell adhesion, plays a crucial role in epithelial-to-mesenchymal transition (EMT) by facilitating…
Vimentin in Epithelial-to-Mesenchymal Transition (EMT)
Vimentin is a type III intermediate filament protein that plays a pivotal role in the structural reorganization and phenotypic transformation…
E-cadherin in Epithelial-to-Mesenchymal Transition (EMT)
E-cadherin, or epithelial cadherin, is a transmembrane glycoprotein that plays a fundamental role in maintaining the structure and integrity of…